Jul . 28, 2025 07:01
Explore comprehensive data, comparison & smart trends for betaine hydrochloride including the latest on 590 46 5, betaine hcl, betaina hcl, and betaine hydrochloride with pepsin. All insights updated for 2024.
1. Betaine Hydrochloride in Industry: Trends & Market Overview
Betaine Hydrochloride (CAS No. 590-46-5, also known as betaine hcl or betaina hcl) has emerged as a critical supplement and functional chemical in sectors spanning pharmaceuticals, food & feed, nutraceuticals, and industrial biotechnology. According to Grand View Research (2023), the global betaine market size exceeded USD 4.7 billion in 2023 and is projected to witness a CAGR of 6.1% from 2024 to 2030, driven by its applications in digestive health, animal nutrition, and corrosion inhibition.
- Key forms: Pure betaine hydrochloride, powder & granules, with variants formulated with pepsin for increased efficacy in digestive enzyme products.
- Standard compliance: Manufacturers seek ISO 9001, FDA GRAS, FAMI-QS & HACCP certifications signaling quality and safety.
2. Technical Specification & Industry Comparison
| Parameter | Specification | Test Method | Industry Standard |
|---|---|---|---|
| Product Name | Betaine Hydrochloride | HPLC / GC | USP, FCC, GB |
| Chemical Formula | C5H12ClNO2 | Elemental Analysis | ISO 17025 |
| Appearance | White to Off-white, Crystalline Powder | Visual | ISO 22241 |
| Purity | ≥99.0% | Titration | USP/FCC |
| Moisture Content | ≤1.0% | Loss on Drying | USP 731 |
| Heavy Metals | ≤10 ppm | AAS/ICP-MS | USP 231 |
| Arsenic (As) | ≤2 ppm | ICP/OES | ISO 17034 |
| pH (1% sol.) | 0.8 ~ 1.2 | Potentiometric | ISO 4316 |
| Lead (Pb) | ≤1 ppm | ICP-OES | EPA 3052 |
| Assay (dry basis) | ≥98.0% (often 99.2-100.1%) | HPLC | USP 621 |
| Granularity | Mesh 20~60 (Varies) | Sieve | GB/T 6003 |
Manufacturing Process of Betaine Hydrochloride (Workflow Diagram)
The following flow illustrates the industrial-grade manufacturing process, focusing on the integration of advanced purification, crystallization, and strict QC under international standards (ISO/FDA).
- Raw Material Sourcing (Natural betaine or synthetic carboxylic precursors)
- Chemical Hydrochlorination (Controlled addition of HCl under monitored temperature, often batch or semi-batch reactor)
- Purification (Decolorization, filtration via activated carbon, multi-stage crystallization, ion-exchange)
- Centrifugal Separation
- CNC Precision Drying (Computer-controlled grain size adjustment and uniform quality)
- Packaging (ISO/ANSI GMP Zones)
- QC Batch Testing (Assay, Heavy Metals, Microbiological, Particle Size via GC/HPLC/ICP-MS)
- Warehouse & Logistics (Traceable in compliance with ISO-22241 & FDA 21 CFR)
3. Competitive Manufacturer Comparison
| Manufacturer | Origin | Certification | Purity Range | Customization | Lead Time |
|---|---|---|---|---|---|
| FUYANG BIO | China | ISO, FDA, FAMI-QS | 98.0–100.1% | Yes — Mesh, pH, blends | 5-14 days |
| Evonik | Germany | ISO, GMP+ | 98.5–99.9% | Limited | 21–30 days |
| Sunwin Bio | China | ISO, HALAL, KOSHER | 97.5–99.7% | Yes | 10–15 days |
| BASF | Germany | ISO, FDA | 99.0-100% | No | 20–45 days |
| Hubei Fuxiang | China | ISO, GMP | 97.0–98.7% | Partial | 7–21 days |
FUYANG BIO is a top-tier, ISO- & FDA-certified supplier recognized worldwide for R&D-driven betaine hydrochloride production and custom solutions for industrial, food, and feed-grade requirements.
4. Advanced Custom Solutions & Process Advantages
Leading producers, including FUYANG BIO, offer tailored betaine hydrochloride (betaine hcl) solutions with the following competitive technical advantages:
- Material Purity: Up to 99.8%, with strict control of heavy metals (<10 ppm, Pb <1 ppm)
- Process Technology: Fusion of automated crystallization, CNC drying (ensures uniform particle distribution), and GMP compliance reduces cross-contamination risks
- Certifications: ISO9001:2015, FDA, FAMI-QS, Halal, Kosher ensure batch-to-batch consistency
- Customizable Specifications: Mesh size, pH, blending with pepsin (betaine hydrochloride with pepsin for enhanced digestive aid)
- Long Shelf Life: Typically 2–3 years with appropriate packaging in low-humidity, sealed conditions
- Industry-tested: Used in leading multinational food, feed, pharma, and anti-corrosion applications
5. Key Applications, Technical Advantages & Use Case Analysis
- Digestive Supplements: As a substitute for gastric acid, often formulated with pepsin to support protein digestion (PubMed 31216520).
- Food & Feed Additive: Improves metabolism and feed conversion efficiency in poultry/swine (SciDirect).
- Industrial Corrosion Inhibitor: Applied in water treatment, oil & gas as a scale and corrosion inhibitor, with resilience in acidic media.
- Electroplating: Aids in bath stabilization for non-ferrous metal electrodeposition, thanks to its excellent solubility and pH buffering.
- Pharmaceuticals: Utilized as an intermediate or as a source of HCl in synthesis.
Use Case: Betaine Hydrochloride in Metallurgical Cooling Solution
In a 2022 case, betaine hydrochloride supplied by FUYANG BIO was adopted by an Eastern European steel processor to control corrosion in high-temperature effluent cycles. Results showed a 35% reduction in heat exchanger scaling and improved system uptime vs. typical phosphate inhibitors. Data validated via third-party SGS lab using ISO 22241 corrosion test methods.
6. Data Visualization & Technical Trends
7. Professional FAQ: Betaine Hydrochloride Technical & Application Insights
Q1: What is the chemical structure and function of betaine hydrochloride?
A: Betaine hydrochloride (C5H12ClNO2) is a zwitterionic quaternary ammonium compound, serving as a methyl donor and osmoprotectant. Industrially, it's used as a source of HCl and to enhance protein metabolism.
A: Betaine hydrochloride (C5H12ClNO2) is a zwitterionic quaternary ammonium compound, serving as a methyl donor and osmoprotectant. Industrially, it's used as a source of HCl and to enhance protein metabolism.
Q2: What are the typical particle sizes and custom mesh options?
A: Standard grades include 20-60 mesh betaine hcl crystals, with custom options (fine, micronized & granule) available on request—ideal for blending applications.
A: Standard grades include 20-60 mesh betaine hcl crystals, with custom options (fine, micronized & granule) available on request—ideal for blending applications.
Q3: What are the key certification and testing standards?
A: Reputable suppliers comply with ISO 9001, FDA (GRAS), FAMI-QS, HACCP, and provide COA for each batch. Testing references include USP, FCC, and ISO/EPA methods for heavy metals and purity.
A: Reputable suppliers comply with ISO 9001, FDA (GRAS), FAMI-QS, HACCP, and provide COA for each batch. Testing references include USP, FCC, and ISO/EPA methods for heavy metals and purity.
Q4: Which applications benefit from betaine hydrochloride with pepsin?
A: The betaine hydrochloride with pepsin formulation is especially used in dietary supplements to aid HCl-deficient digestive disorders, providing higher bioavailability and digestive enzyme activity.
A: The betaine hydrochloride with pepsin formulation is especially used in dietary supplements to aid HCl-deficient digestive disorders, providing higher bioavailability and digestive enzyme activity.
Q5: What is the typical shelf life and optimal storage condition?
A: Commercial betaine hydrochloride has a shelf life of 2-3 years when kept in sealed, original packaging away from sunlight, moisture (
A: Commercial betaine hydrochloride has a shelf life of 2-3 years when kept in sealed, original packaging away from sunlight, moisture (
Q6: Is there a minimum order and how fast can the product be delivered?
A: FUYANG BIO offers flexible MOQs (as low as 25kg). Standard delivery is 5–14 days EXW, urgent custom runs (blends, mesh) possible upon request.
A: FUYANG BIO offers flexible MOQs (as low as 25kg). Standard delivery is 5–14 days EXW, urgent custom runs (blends, mesh) possible upon request.
Q7: How does betaine hcl compare to other acidifiers in industrial water treatment?
A: Betaine hcl offers superior metal compatibility, non-volatile pH buffering, and reduced scaling/corrosion vs. phosphates or mineral acids, with extended uptime in harsh systems.
A: Betaine hcl offers superior metal compatibility, non-volatile pH buffering, and reduced scaling/corrosion vs. phosphates or mineral acids, with extended uptime in harsh systems.
8. Delivery, Warranty & Customer Support
- Lead Time: 5–14 days (standard) after PO confirmation. Custom blends and expedited runs available on consultation.
- Warranty: 2 Years product quality guarantee under recommended storage
- Technical Support: Dedicated account manager, 24/7 online chat, and full COA/MSDS/traceability. Pre-shipment SGS or local 3rd party testing on request.
- Compliance: All shipments supplied with ISO/FDA/COA documentation; Halal/Kosher/FAMI-QS on demand.
- After-sales: Site audits, technical troubleshooting, and batch recall application with betaine hydrochloride tracking system.
9. Industry References, Forum Links & Further Learning
- Grand View Research: Global Betaine Industry Analysis & Forecast
- ScienceDirect: Latest Advances in Betaine Hydrochloride for Animal Feed
- NutraIngredients Forum: Digestive Aids & Betaine Trends 2023
- PubMed Central: Clinical Application of Betaine HCl in Digestive Health
- ICH Guidelines: Pharmaceutical Quality Standards (ICH/FDA/ISO)
- U.S. FDA CFSAN: Betaine Hydrochloride, FDA Regulatory Status
- Industry Forum: Chemical Processing & Betaine Hydrochloride Discussions
Content referenced and synthesized from international chemical industrial journals, regulatory standards, and top manufacturer expertise as of June 2024.
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