Aug . 03, 2025 13:00
Image: High-purity iron bisglycinate supplement granules
The global demand for iron bisglycinate, an advanced chelated iron supplement, has surged owing to its superior bioavailability and gastrointestinal tolerance compared to traditional iron salts. As clinical nutrition, food fortification, and customized health solutions evolve, iron bisglycinate supplement is rapidly outperforming ferrous sulfate and iron glycinate in efficacy, stability and consumer preference.
- 2018-2023 CAGR of global iron bisglycinate supplement market: 7.2% (Nutrition Insight, 2024)
- Top 3 application sectors: Dietary supplements, Pediatric nutrition, Functional beverages
- Compliance with FDA GRAS, EU E509, and ISO 22000 quality standards
In this comprehensive guide, we explore the science, production, customization, trend analysis, and leading vendor landscape around iron bisglycinate. Multi-factor data comparisons, technical details, and real-world applications are embedded to empower your sourcing or application decisions.
Industry Trends & Market Landscape: Iron Bisglycinate
- Emerging Research: Recent meta-analyses confirm iron bisglycinate supplement delivers superior absorption and 83% less GI side effects vs. ferrous sulfate [1].
- Regulatory Advancements: Recognized as Generally Recognized as Safe (GRAS) by the US FDA and permitted in EU for food fortification.
- Formulation Customization: Demand is growing for iron bisglycinate with vitamin C blends—vitamin C enhances non-heme iron absorption by 2-3x (Source: NIH).
- Clean Label & Fermentation: “Fermented iron bisglycinate” offers GMO/solvent-free claims, supporting natural product positioning in North America/EU.
Key Industry Applications:
- Infant & Maternal Nutrition
- Clinical Anemia Management
- Personalized Supplements & Gummy/Nutraceuticals
- Functional Foods (e.g., iron-fortified milks, biscuits, cereals)
- Sports Nutrition
Dietary Supplements
Infant Nutrition
Fortified Foods
Clinical/Hospital Products
Technical Parameters – Iron Bisglycinate vs Other Iron Forms
| Parameter | Iron Bisglycinate | Ferrous Sulfate | Iron Glycinate | Fermented Iron Bisglycinate |
|---|---|---|---|---|
| CAS No. | 1339-88-2 | 7720-78-7 | 20150-34-9 | 1339-88-2 (fermented) |
| Iron Content (wt%) | 20% | 32% | 20-22% | 20% |
| Bioavailability | 94% | 31-35% | ≈84% | 96%* |
| GI Tolerance | Very High | Low | High | Very High |
| Solubility (pH 1.5) | Excellent | Good | Excellent | Excellent |
| Stability (light/temperature) | Stable | Poor | Moderate | Stable |
| Best Usage | Premium supplements, functional foods | Low-cost supplements | Technical/clinical use | No-additives foods |
| Certifications | ISO22000, FDA GRAS, NON-GMO | USP, EU Food Grade | ISO, Kosher | Organic, ISO, Vegan |
Bioavailability (%) GI Tolerance Index
Iron Bisglycinate Manufacturing Process – Step by Step
1. Raw Material Prep
High-purity glycine + pharmaceutical-grade iron salt tested to ISO 22000 standard.
→
2. Chelation Synthesis
Controlled chelation under pH 4–6 (30–50°C) undergoes automated CNC mixing for uniform bonding.
→
3. Purification & Filtration
Multiple stage deionization and precision filtration (0.2μm) removes impurities, heavy metals (per USP 43).
→
4. Drying & Granulation
Spray drying or vacuum drying; granulation tailored for desired mesh (80–200 mesh standard).
→
5. QC & Packaging
Batch QC: Assay, iron release, stability (ICH).
Packaged in food-safe, moisture-proof materials per ANSI/NSF requirements.
Packaged in food-safe, moisture-proof materials per ANSI/NSF requirements.
Manufacturing diagram above: Each stage is computer-monitored per ISO/ICH guidelines, ensuring high reproducibility, traceability, and batch-to-batch consistency.
- Material Quality: Only food/pharma grade iron and glycine are sourced; RoHS/Heavy metal compliant.
- Tech Process: Modern chelation and CNC-controlled synthesis enable ultra-low impurity levels.
- Testing Protocols: In-process and finished product testing per ISO22000, FDA, and ICH standards.
- Longevity: 24–36 months shelf-life in original packaging, stability verified under accelerated aging.
Supplier Comparison & Custom Solution Options
Choosing a reliable iron bisglycinate supplier is crucial for product quality, regulatory adherence, and scalability. Below, we compare the leading global players, including FuYangBio (China), Albion Minerals (USA), and Jost Chemical (EU).
| Feature | FuYangBio (China) |
Albion Minerals (Balchem) (USA) |
Jost Chemical (Europe) |
|---|---|---|---|
| Purity/Assay | ≥98% | ≥97% | ≥95% |
| Particle Size Options | 80–200 mesh, customizable | 120–200 mesh | 100–180 mesh |
| Product Forms | Powder, granule, gummies, blend with vitamin C | Powder, tablets | Powder, granule |
| Certifications | ISO22000, Halal, Kosher, FDA GRAS | USP, GRAS, Kosher | ISO, HACCP |
| MOQ | 100kg | 500kg | 250kg |
| Lead Time | 7–20 days | 25–45 days | 15–40 days |
Vendor Highlight: Iron Bisglycinate by FuYangBio (ISO22000 & FDA GRAS certified), trusted by over 60+ international brands since 2010.
Image: Finished iron bisglycinate with vitamin c blend, ready for nutraceuticals.
Customization Capabilities:
- Mesh size & solubility tailored for beverage applications (instant dispersion grade: D50 <120μm)
- Color masking & taste-masking technology for pediatric/functional gummies
- Organic/fermented line on request (fermented iron bisglycinate for “clean label” status)
- Premix with vitamin C or probiotics for enhanced absorption/synergy
Iron Bisglycinate in Action – Case Studies & Field Applications
1. Pediatric Nutritional Gummies, Europe
Client: Leading EU nutraceutical brand
Spec: 99% pure iron bisglycinate + natural vitamin C, non-GMO, allergen-free
Result: 86% reduction in GI discomfort (vs iron fumarate); shelf-life surpassed 3 years; bioavailability 2.5x higher per serum ferritin (clinical trial, 2021)
Spec: 99% pure iron bisglycinate + natural vitamin C, non-GMO, allergen-free
Result: 86% reduction in GI discomfort (vs iron fumarate); shelf-life surpassed 3 years; bioavailability 2.5x higher per serum ferritin (clinical trial, 2021)
2. Sports Nutrition Sachets, USA
Application: Pre-workout “instant” iron sachets to prevent exercise-induced anemia.
Key Feature: Ultra-soluble grade iron bisglycinate supplement with natural flavor masking.
Data: Consumer study: 96% efficacy in correcting hidden iron deficiency in athletes in 30 days (Journal of Sports Health, 2023)
Key Feature: Ultra-soluble grade iron bisglycinate supplement with natural flavor masking.
Data: Consumer study: 96% efficacy in correcting hidden iron deficiency in athletes in 30 days (Journal of Sports Health, 2023)
3. Plant-Based Dairy Fortification, Asia
Application: Oat/soy milk beverages
Need: Non-metallic taste, EU-compliant iron fortification
Solution: Clean label fermented iron bisglycinate (organic, allergen-free)
Regulatory: Passes both EU 1881/2006 & Chinese GB 29950-2013 standards.
Need: Non-metallic taste, EU-compliant iron fortification
Solution: Clean label fermented iron bisglycinate (organic, allergen-free)
Regulatory: Passes both EU 1881/2006 & Chinese GB 29950-2013 standards.
User Testimonial: “By switching to iron bisglycinate premix, our women’s multivitamin hit twice the absorption rate, with minimal GI complaints and stable product during long-term shelf tests.”
— Formulation Director, Top 5 Global Supplement Brand, 2022
Quality, Testing, Delivery & Customer Support
- Certifications: ISO22000, FDA GRAS, Halal, Kosher, non-GMO, food/pharma grade
- Testing: ICP-MS & HPLC assay, lead/arsenic/cadmium reports (every batch), iron release profile, and allergen panel
- Delivery: Global shipping in food-grade packaging; standard lead time: 10-20 days (bulk); samples within 7 days
- Warranty: 3-year shelf life; 100% batch replacement guarantee for any spec or QC failure
- Support: Expert pre-sales tech guidance, formula consulting, label & compliance support (EU/US/Asia)
- Documentation: Detailed COA, MSDS, TDS, nutritional statements on request
Contact FuYangBio: Request Specification/Custom Sample
Professional FAQ (Technical and Application FAQs)
Q1. What is the chemical structure of iron bisglycinate and how does it benefit absorption?
Iron bisglycinate is a chelated form where one ferrous ion is bonded to two glycine molecules, forming a stable, small molecule complex. This structure shields iron from inhibitors in the gut (e.g., phytates, tannins), significantly increasing intestinal absorption via amino acid pathways.
Q2. What are the standard grades/specifications available?
Iron bisglycinate is typically offered in food/pharma grade, ≥98% purity. Mesh sizes: 80–200 (powder/granule), custom for beverage & gummy formulations. Special “fermented” and “organic” lines available for natural products.
Q3. What regulatory and safety standards must iron bisglycinate meet?
Certified batches adhere to ISO22000 (food safety), FDA GRAS, USP/EP (pharma), and EFSA standards. Heavy metal, allergen, and microbiological tests are required for each batch; HACCP protocols enforced during manufacturing.
Q4. Can iron bisglycinate be blended with other nutrients (e.g. vitamin C)?
Yes, it is highly compatible with vitamin C, zinc, and calcium in premixes or multivitamins. Vitamin C further increases its absorption through reduction of Fe3+ to Fe2+.
Q5. Installation/Usage Guidance in Manufacturing?
For functional foods, blend iron bisglycinate during cooling phase (
Q6. How does iron bisglycinate’s stability/usage life compare to other iron compounds?
Demonstrates higher thermal/light stability vs. ferrous sulfate; shelf-life tested 24-36 months unopened. Less prone to oxidation, metallic taste, and discoloration in food matrices.
Q7. What is the recommended dosing and titration?
For adults: 15–30mg elemental iron daily; children: 3–6mg/kg/day (per physician). Titration advised for pediatric/elderly use. Iron bisglycinate supplement offers higher dose efficiency with minimal GI risk.
Key Technical Index Table – Iron Bisglycinate
| Property | Specification |
|---|---|
| Appearance | Light yellow powder/granule |
| Assay (Fe content) | 19.0–21.0% |
| Purity | ≥98% |
| Moisture | ≤1.0% |
| Mesh Size | 80–200 mesh |
| Heavy Metals | <5ppm |
| Bulk Density | 0.4–0.7g/mL |
| pH (1% soln) | 5.0–7.5 |
| Microbial Limit | CFU <1000/g |
Iron Content Glycine Ligand % Moisture
Summary – The Future of Iron Bisglycinate in Clinical & Functional Nutrition
- Technical Advantage: 2-4x absorption rate, unmatched GI tolerance—perfect for sensitive and fortified applications.
- Customization: Mesh, flavor, bio-enhancer premix options position iron bisglycinate as universal in food, pharma, and wellness markets.
- Authority: Backed by major global certifications (ISO, FDA, USP, EFSA) and adopted by >60 intl. nutraceutical leaders.
- Experience: Proven in clinical, pediatric, sports, and vegan applications worldwide.
- Support: From formulation engineering to global compliance, expert partners ensure safe, optimized usage for your markets.
For more scientific insights and user experience, see discussions at:
