S-(Carboxymethyl) -L-cysteine

Indima kunye nokusebenza kakuhle kwe-S-(Carboxymethyl) -L-cysteine kwiMpilo yeZilwanyana S-(Carboxymethyl) -L-cysteine (eyaziwa ngokuba yiCarbocysteine) iphuma kwi-cysteine kwaye ivela kwiklasi ye-mucoregulator kunye ne-antioxidant, efana ne-acetylcysteine (NAC). Nangona kunjalo, ukwakhiwa kwayo kweekhemikhali kunye nendlela yokwenza izinto zihluke kakhulu. Apha ngezantsi sisishwankathelo seendima zayo kunye nenkqubela phambili yophando kwimpilo yezilwanyana:

Intshayelelo yeMveliso

Inombolo yeCAS: 2387-59-9

Ifomula yemolekyuli:C₅H₉NO₄S

Ubunzima beMolekyuli: 179.19

EINECS NO.: 219-193-9

Indima kunye nokuSebenza kwe S-(Carboxymethyl) -L-cysteine kwiMpilo yeZilwanyana...

I-S-(Carboxymethyl) -L-cysteine (eyaziwa ngokuba yiCarbocysteine) iphuma kwi-cysteine kwaye iyingxenye ye-mucoregulator kunye neklasi ye-antioxidant, efana ne-acetylcysteine (NAC). Nangona kunjalo, ukwakhiwa kwayo kweekhemikhali kunye nendlela yokwenza izinto zihluke kakhulu. Apha ngezantsi sisishwankathelo seendima zayo kunye nenkqubela phambili yophando kwimpilo yezilwanyana:

...I. IiNdlela ezingundoqo kunye neziphumo...

...1. Ukukhuselwa kwe-Mucolytic kunye nokuPhumla...

...Isenzo: Ilawula ukukhutshwa kwe-mucus yomoya kunye nokunciphisa i-sputum viscosity ngokumodareyitha umsebenzi we-enzyme ehambelana nokuveliswa kwe-mucus (ngokungafaniyo ne-NAC, eyaphula ngokuthe ngqo i-mucus nge-disulfide bond cleavage).
...Iintlobo ekujoliswe kuzo:

...Izilwanyana zasekhaya (izinja/iikati): Ibronchitis engapheliyo, inyumoniya enesikhohlela esingqindilili.

...Imfuyo (iinkomo/iihagu): Usulelo lwentsholongwane okanye lwentsholongwane yokuphefumla (umzekelo, inyumoniya yehagu enzootic).

...2. I-Antioxidant kunye ne-Anti-inflammatory Effects...

...Inkqubo: Yandisa amanqanaba e-intracellular glutathione (GSH) kwaye icinezela i-cytokines e-pro-inflammatory (umzekelo, i-IL-8, i-TNF-α), ukunciphisa ukuvutha kwendlela yomoya.
...Usetyenziso:

...Iinkukhu: Inciphisa umonakalo we-oxidative ukusuka kwi-ammonia okanye ukuvezwa kothuli.
...Inkcubeko yasemanzini: Ikhusela kuxinzelelo lwe-oxidative kwiindawo zokulima ezixinana kakhulu.

...3. Immunomodulation...

Yomeleza ukhuselo lwe-mucosal kwaye inokuphucula ukusebenza kogonyo (umzekelo, kwi-porcine respiratory disease syndrome).

II. Ukuthelekiswa ne-Acetylcysteine (NAC)...

Uphawu	S-(Carboxymethyl)-L-cysteine	I-Acetylcysteine (NAC)
Inkqubo	Ngokungangqalanga kunciphisa ukubonwa kwesikhohlela ngolawulo lwe-mucus	Ngokuthe ngqo iqhekeza iibhondi ze-disulfide kwi-mucus
Ukuqalisa kweNtshukumo	Kancinci (ifuna idosi ezinzileyo)	Ngokukhawuleza (isebenza kwiiyure nje ezimbalwa)
Uphawu	S-(Carboxymethyl)-L-cysteine	I-Acetylcysteine (NAC)
Umthamo weAntioxidant	Iphakathi (ixhomekeke kwi-GSH synthesis)	Eyomeleleyo (ingqale ngqo simahla ngokurhabula ngokusebenzisa amaqela e-SH)
Amatyala okusetyenziswa okuPhambili	Izifo ezingapheliyo zokuphefumla, ukhathalelo lokuthintela	Ityhefu ebukhali, uxinzelelo olukhulu lwe-oxidative, okanye ukuvaleka kwendlela yomoya
Inkangeleko yoKhuseleko	Iziphumo ebezingalindelekanga ezimbalwa zesisu	Inokubangela ukugabha kwizilwanyana ze-monogastric

...

III. Uphando kunye nezicelo kwiMpilo yeZilwanyana...

...1. Ukufuya iinkukhu...

...Idatha yovavanyo‌: Ukongeza i-S-(Carboxymethyl)-L-cysteine (50–100 mg/kg) kwisondlo sebroiler kunciphisa izilonda zokuphefumla ezibangelwa kukutyhileka kwe-ammonia kwaye kuphuculwe ukufumana ubunzima nge-5–8%.
...Ulawulo: Ngokusebenzisa amanzi okusela okanye ukutya kangangeentsuku ezi-5–7.

...2. Izilwanyana zasekhaya (Izinja/Iikati)...

...Ulawulo lwebronchitis engapheliyo: Ukujongwa ngomlomo kwi-10-15 mg / kg kabini yonke imihla kwiiveki ezi-2 kunciphisa kakhulu ukukhwehlela.

...3. Inkcubeko yasemanzini...

...Ukhuseleko loxinzelelo: Ukongezwa kokutya (200-300 mg / kg) kunciphisa umonakalo we-oxidative ngexesha lokuthutha okanye iimeko ezimbi zamanzi, ukuphucula amazinga okuphila.

...IV. Ukulumkela...

...Ulawulo lwedosi:

Ukugqithisa ngokweqile kunokubangela urhudo olungephi (ingakumbi kwiinkukhu).

...Ukusebenzisana kweziyobisi:

Gwema ukusetyenziswa ngaxeshanye kunye ne-acidic agents (umzekelo, i-vitamin C) okanye i-antibiotics (umzekelo, i-tetracyclines).

...Ukuthotyelwa koMgaqo:

...eTshayina: Kufuneka uhambelane nayo Imimiselo yoLawulo lweZilwanyanakunye namaxesha okurhoxisa.
...i-EU: Ayikavunywa njengechiza eliqhelekileyo lonyango lwezilwanyana; landela imimiselo yendawo.

...V. Izikhokelo zoPhando ezinokwenzeka...

...I-Antiviral Adjuvant: Uphononongo lwe-in vitro lucebisa uthintelo lwe-avian influenza virus (H9N2) ukuphindaphinda; kufuneka uqinisekiso olongezelelweyo.
...Impilo yeNzala: Iphucula isakhono se-antioxidant samadlozi okanye i-oocyte ekuzaleni izilwanyana (inqanaba lovavanyo).

...Isishwankathelo...

S-(Carboxymethyl) -L-cysteine isetyenziswa ikakhulu kwimpilo yezilwanyana kwi-ulawulo lwezifo ezingapheliyo zokuphefumlakwayeinkxaso yokukhusela i-antioxidant. Isenzo sayo esithambileyo kunye neprofayili ephezulu yokhuseleko yenza ukuba ilungele ukusetyenziswa kwexesha elide, nangona ukuqala kwayo kancinci kunciphisa usetyenziso kwiimeko ezinzima. Xa zidityaniswe ne-NAC, ezi arhente zimbini ziyancedisana ekujonganeni nemingeni yempilo engapheliyo kunye nebukhali. Ukusetyenziswa okusebenzayo kufuneka kuthathelwe ingqalelo iimfuno zohlobo oluthile, amanqanaba ezifo, kunye nezikhokelo zolawulo.

Ngeembekiselo zovavanyo oluneenkcukacha okanye iiprothokholi ezenziwe ngokwezifiso, zive ukhululekile ukubuza!

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s carboxymethyl l cysteine

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