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Inombolo yeCAS: 616-91-1
Ifomula yemolekyuli:C₅H₉NO₃S
Ubunzima beMolekyuli: 163.20
EINECS NO.: 211-806-2
I-Acetylcysteine (NAC) kwi-Veterinary Medicine: Imisebenzi engundoqo, izicelo, kunye neziKhokelo
...
...I. IiNdlela ezingundoqo kunye neziphumo zonyango...
...1. I-Detoxification kunye ne-Hepatoprotection...
...I-Acetaminophen (Paracetamol) Ityhefu...
- ...Inkqubo: Izalisa i-glutathione (GSH) ukuze inciphise i-NAPQI ye-metabolites enetyhefu, ikhusela i-hepatic necrosis.
- ...Isicelo: Unyango olungxamisekileyo kwizinja/iikati eziginya amayeza ane-acetaminophen (umzekelo, amayeza abandayo).
...Umthamo: 70-140 mg / kg IV okanye ngomlomo, iphindwe rhoqo kwiiyure ze-4-6.
- ...Ukusebenza kakuhle: > 60% yokuphucula izinga lokusinda ukuba ilawulwa kwiiyure ezisi-8 emva kokugalelwa ityhefu.
...Isinyithi esinzima kunye noCwangciso lweToxin...
- ...Chelation: Ibophelela ilothe/imercury ngokusebenzisa amaqela e-sulfhydryl (-SH) (ahlala edityaniswa ne-EDTA).
- ...Mycotoxin Detox: Yehlisa umonakalo wesibindi owenziwe yi-aflatoxin kwi-B1 kwinkukhu (200 mg/kg i-NAC yehlisa i-ALT ngama-50%).
...2. Ulawulo lwezifo zokuphefumla...
...I-Mucolytic kunye ne-Expectorant Effects...
- ...Isenzo: Wophula iibhondi ze-disulfide kwi-mucus, ukunciphisa i-viscosity kunye nokuphucula ukuhamba komoya.
- ...Iimpawu:
- ...Izilwanyana zasekhayaUkukrala kwesifuba, inyumoniya (ukhohlokhohlo/idyspnea).
- ...Imfuyo: Usulelo lwebhaktiriya/yintsholongwane yokuphefumla (umzekelo, inyumoniya yehagu enzootic).
- ...Ulawulo:
- I-Nebulization (i-3-5% isisombululo) okanye ngomlomo (10-20 mg / kg BID).
...I-Anti-inflammatory kunye ne-Immunomodulatory Effects...
- ...Inkqubo: Icinezela i-IL-6, i-TNF-α, kwaye ithomalalisa ukudumba okungapheliyo (umzekelo, ukuvalwa kwendlela yomoya elinganayo).
...3. Iimpawu ze-Antioxidant kunye ne-Anti-stress...
...Ukukhuselwa koxinzelelo lwe-Oxidative...
- ...Inkqubo: Yongeza i-GSH ye-intracellular, ikhupha ii-radicals zamahhala, kwaye ikhusela ingqibelelo yeselula.
- ...Usetyenziso:
- ...Iinkukhu: Ukunciphisa uxinzelelo lobushushu (100 mg/kg i-NAC kwisondlo iphucula imveliso yeqanda nge-5–8%).
- ...Inkcubeko yasemanzini: Yehlisa umonakalo owenziwe nge-oxidative ngexesha lothutho/ukulima ngokuxinana okuphezulu.
...Ukomelezwa kwamajoni omzimba...
- Ivuselela ukwanda kwe-lymphocyte kwaye iphucula ukusebenza kakuhle kwesitofu sokugonya (umzekelo, ukugonywa kwe-hagu fever).
II. Iintlobo-izicelo ezikhethekileyo...
| Udidi lwezilwanyana | Ukusetyenziswa okungundoqo | Umthamo ocetyiswayo | |
| Izinja / Iikati | I-acetaminophen detox, i-bronchitis engapheliyo | IV: 70-140 mg / kg, amaxabiso ahlukeneyo | |
| Iinkukhu (Iinkuku/Amadada). | Mycotoxin detox, uxinzelelo lobushushu, ukuphefumla | Amanzi okusela: 100-200 mg / L iintsuku ezi-3-5 | |
| Ezelusayo (Iinkomo). | Ukukhuselwa kweAflatoxin, inyumoniya yethole | Umlomo: 20 mg / kg BID | |
| Amanzi (Intlanzi/iShrimp). | Uxinzelelo lwezothutho, imingeni yomgangatho wamanzi | Isongezo sokutya: 200-500 mg / kg |
...III. Ukusetyenziswa koLumkelo...
...Ulawulo lwedosi:
- Ukugqithisa ngokweqile kunokubangela ukuhlanza / isifo sohudo (ingakumbi kwi-monogastrics); Ukutofa okucothayo kwe-IV ukuphepha i-hypotension.
- Lungiselela izisombululo zeNAC ezitsha zenkukhu (i-oxidation ekhawulezayo emanzini).
...Ukusebenzisana kweziyobisi:
Gwema ukusetyenziswa ngaxeshanye kunye ne-oxidizers (umzekelo, i-potassium permanganate) okanye i-antibiotics (umzekelo, i-penicillin); lawula iiyure ezi-2 ngaphandle.
...Ukuthotyelwa koMgaqo:
- ...i-EU: Ivunyiwe kwizalathisi ezithile (umzekelo, ukukhupha ubuthi) kunye nemida yentsalela kwizilwanyana ezityayo.
- ...eTshayina: Landela Imigaqo yoLawulo lweZilwanyana zeZiyobisikunye namaxesha okurhoxisa.
...IV. UPhando oluPhambili kunye noSetyenziso olunokubakho...
- ...I-Antiviral Adjunct: Ithintela ukuphindaphinda kwePRRSV kwi-vitro (50 μM ugxininiso olusebenzayo).
- ...Impilo yeNzala: Iphucula umgangatho wamadlozi kwiinkunzi (ukwandisa nge-15% kwi-sperm motility).
...V. Isishwankathelo...
I-Acetylcysteine isebenza njengelitye lembombo kunyango lwezilwanyanai-detoxification, inkxaso ye-antioxidant, kunye nokhathalelo lokuphefumla, ukujongana neemeko ezingxamisekileyo zetyhefu, izifo ezingapheliyo, kunye noxinzelelo lokusingqongileyo. Isicelo esikhuselekileyo nesisebenzayo sidinga idosi yohlobo oluthile, ukuthotyelwa kwemimiselo, kunye nezicwangciso zonyango ezilungiselelweyo.
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