N-Acetylcysteine

Nomoro ea CAS: 616-91-1

Foromo ea molek'hule:C₅H₉NO₃S

Boima ba Limolek'hule: 163.20

Nomoro ea EINECS: 211-806-2

Acetylcysteine ​​(NAC) ho Meriana ea Liphoofolo: Mesebetsi ea Bohareng, Likopo, le Litaelo

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"I. Mekhoa ea Motheo le Liphello Tsa Phekolo"

"1. Detoxification le Hepatoprotection"

"Acetaminophen (Paracetamol) Chefo"

• "Mokhoa: E tlatsa glutathione (GSH) ho fokotsa metabolites e chefo ea NAPQI, ho thibela necrosis ea sebete.
• "Kopo: Kalafo ea tšohanyetso bakeng sa lintja/ likatse tse noang meriana e nang le acetaminophen (mohlala, litlhare tsa sefuba).

"Tekanyetso70-140 mg / kg IV kapa ka molomo, e phetoa lihora tse ling le tse ling tse 4-6.

• "Katleho:> 60% ea ntlafatso ea sekhahla sa ho pholoha haeba e fanoa nakong ea lihora tse 8 kamora ho chefo.

"Ho Hlakola Metako e Meli le Chefo"

• "Chelation: E kopanya lead/mercury ka lihlopha tsa sulfhydryl (-SH) (hangata li kopantsoe le EDTA).
• "Mycotoxin Detox: E fokotsa tšenyo ea sebete e bakoang ke aflatoxin B1 likhoho (200 mg/kg NAC e theola ALT ka 50%).

"2. Taolo ea Mafu a Phefumolohang"

"Liphello tsa Mucolytic le Expectorant"

• "Ketso: E khaola maqhama a disulfide ka har'a mucus, e fokotsa viscosity le ho ntlafatsa phallo ea moea.
• "Lipontšo:
  • "Liphoofolo tse ruuoang lapeng: Bronchitis, pneumonia (khohlela / dyspnea).
  • "Meruo: Tšoaetso ea baktheria/vaerase ea ho hema (mohlala, pneumonia enzootic ea likolobe).
• "Tsamaiso:
  • Nebulization (3–5%) kapa ka molomo (10–20 mg/kg BID).

"Anti-inflammatory le Immunomodulatory Effects"

• "Mokhoa: E hatella IL-6, TNF-α, 'me e kokobetsa ho ruruha ho sa foleng (mohlala, tšitiso ea tsela ea moea ea equine khafetsa).

"3. Antioxidant le Anti-stress Properties"

"Tšireletso ea Oxidative Stress"

• "Mokhoa: E matlafatsa GSH ea intracellular, e senya li-radicals tsa mahala, 'me e sireletsa botšepehi ba liselefouno.
• "Lisebelisoa:
  • "Khoho ea likhoho: Ho fokotsa khatello ea mocheso (100 mg/kg NAC phepelong e ntlafatsa tlhahiso ea mahe ka 5-8%).
  • "Tlhapi ea metsing: E fokotsa tšenyo ea oxidative nakong ea lipalangoang / temo e matla haholo.

"Ntlafatso ea 'mele oa ho itšireletsa mafung"

• E susumetsa ho ata ha lymphocyte le ho ntlafatsa katleho ea ente (mohlala, ente ea feberu ea likolobe).

"III. Litlhokomelo tsa Tšebeliso"

"Taolo ea Tekanyo:

• Overdose e ka baka ho hlatsa / letšollo (haholo-holo ho monogastrics); butle-butle IV infusion ho qoba hypotension.
• Lokisetsa litharollo tsa NAC tse ncha bakeng sa likhoho (oxidation e potlakileng metsing).

"Litšebelisano tsa Lithethefatsi:

Qoba ho sebelisa li-oxidizers (mohlala, potassium permanganate) kapa lithibela-mafu (mohlala, penicillin); tsamaisa lihora tse 2 ka thoko.

"Tumellano ea Taolo:

• "EU: E amohetsoe bakeng sa matšoao a ikhethileng (mohlala, detox) ka mesalla ea liphoofolo tse jeoang.
• "ChinaLatela Melawana ea Tsamaiso ea Lithethefatsi tsa Ngaka ea Liphoofolole linako tsa ho tlohela.

"IV. Tsoelo-pele ea Lipatlisiso le Litšebeliso tse ka 'nang tsa Etsoa"

• "Antiviral Ajunct: E thibela phetiso ea PRRSV in vitro (50 μM e sebetsang hantle).
• "Bophelo bo Botle ba Pelehi: E ntlafatsa boleng ba peo ho lipoho (keketseho ea 15% ea ho tsamaea ha peō ea botona).

"V. Kakaretso"

Acetylcysteine ​​​​e sebetsa e le motheo oa meriana ea bongaka ea liphoofolo bakeng sadetoxification, ts'ehetso ea antioxidant, le tlhokomelo ea phefumoloho, ho sebetsana le maemo a tšohanyetso a chefo, mafu a sa foleng, le khatello ea tikoloho. Ts'ebeliso e bolokehileng le e sebetsang e hloka hore ho sebelisoe mefuta e ikhethileng, ho latela melao, le maano a kalafo a hlophisitsoeng.