N-Acetylcysteine

Nambala ya CAS: 616-91-1

Kapangidwe ka Molecular: C₅H₉NO₃S

Kulemera kwa Molecular: 163.20

EINECS NO.: 211-806-2

Acetylcysteine ​​(NAC) mu Veterinary Medicine: Ntchito Zazikulu, Ntchito, ndi Malangizo

pa

paI. Njira Zazikulu ndi Zotsatira Zamankhwalapa

pa1. Kuchotsa poizoni ndi Hepatoprotectionpa

paAcetaminophen (Paracetamol) Poizonipa

• paNjira: Imawonjezera glutathione (GSH) kuti ichepetse ma metabolites apoizoni a NAPQI, kuteteza hepatic necrosis.
• paKugwiritsa ntchito: Chithandizo chadzidzidzi kwa agalu/ amphaka omwe amwa mankhwala okhala ndi acetaminophen (monga mankhwala ozizira).

paMlingo: 70-140 mg / kg IV kapena pakamwa, mobwerezabwereza maola 4-6 aliwonse.

• paKuchita bwino:> 60% kuwongolera kuchuluka kwa kupulumuka ngati kuperekedwa mkati mwa maola 8 pambuyo popha.

paKuchotsa Chitsulo Cholemera ndi Toxinpa

• paChelation: Amamanga lead/mercury kudzera mmagulu a sulfhydryl (-SH) (nthawi zambiri amaphatikizidwa ndi EDTA).
• paMycotoxin Detox: Amachepetsa kuwonongeka kwa chiwindi cha aflatoxin B1 mu nkhuku (200 mg/kg NAC imachepetsa ALT ndi 50%).

pa2. Kusamalira Matenda Opumirapa

paZotsatira za Mucolytic ndi Expectorantpa

• paZochita: Amathyola zomangira za disulfide mukamasi, amachepetsa kukhuthala komanso kuwongolera mpweya.
• paZizindikiro:
  • paZiwetoMatenda: chifuwa, chibayo (chifuwa / kupuma movutikira).
  • paZiweto: Matenda a bakiteriya/ mavairasi opuma (monga chibayo cha nkhumba cha enzootic).
• paUlamuliro:
  • Nebulization (3-5% yankho) kapena pakamwa (10-20 mg/kg BID).

paAnti-inflammatory and Immunomodulatory Effectspa

• paNjira: Imapondereza IL-6, TNF-α, ndipo imachepetsa kutupa kosatha (mwachitsanzo, kutsekeka kobwerezabwereza kwa airway).

pa3. Antioxidant ndi Anti-stress Propertiespa

paChitetezo cha Oxidative Stresspa

• paNjira: Imakulitsa GSH ya intracellular, imachotsa ma free radicals, ndikuteteza kukhulupirika kwa ma cell.
• paMapulogalamu:
  • paNkhuku: Kuchepetsa kupsinjika kwa kutentha (100 mg/kg NAC muzakudya kumathandizira kupanga dzira ndi 5-8%).
  • paZamoyo zam'madzi: Amachepetsa kuwonongeka kwa okosijeni panthawi yamayendedwe/ulimi wochuluka kwambiri.

paKupititsa patsogolo Chitetezo cha mthupipa

• Imalimbikitsa kuchuluka kwa ma lymphocyte ndikuwonjezera mphamvu ya katemera (mwachitsanzo, katemera wa nkhumba).

paIII. Kusamala Kugwiritsa Ntchitopa

paKuwongolera Mlingo:

• Kuchuluka kwa mankhwalawa kungayambitse kusanza / kutsekula m'mimba (makamaka monogastrics); pang'onopang'ono IV kulowetsedwa kupewa hypotension.
• Konzani njira za NAC zatsopano za nkhuku (kutulutsa okosijeni mwachangu m'madzi).

paKugwiritsa Ntchito Mankhwala:

Pewani kugwiritsa ntchito nthawi imodzi ndi okosijeni (mwachitsanzo, potaziyamu permanganate) kapena maantibayotiki (mwachitsanzo, penicillin); perekani 2 hours motalikirana.

paKutsata Malamulo:

• paEU: Kuvomerezedwa pazizindikiro zinazake (monga, kuchotseratu poizoni) wokhala ndi malire otsalira pazakudya.
• paChina: Tsatirani Malamulo pa Utsogoleri wa Zowona Zanyama Mankhwalandi nthawi zochotsa.

paIV. Kafufuzidwe Patsogolo ndi Ntchito Zomwe Zingachitikepa

• paAntiviral Adjunct: Imalepheretsa kubwereza kwa PRRSV mu vitro (50 μM yogwira mtima).
• paUchembere wabwino: Kupititsa patsogolo ubwino wa umuna mu ng'ombe (kuwonjezeka kwa 15% kwa umuna).

paV. Mwachidulepa

Acetylcysteine ​​​​imagwira ntchito ngati mwala wapangodya muzamankhwala azinyamadetoxification, chithandizo cha antioxidant, ndi chisamaliro cha kupuma, kuthana ndi zoopsa zapoizoni, matenda osatha, komanso zovuta zachilengedwe. Kugwiritsa ntchito moyenera komanso moyenera kumafunikira kutengera mtundu wamtundu, kutsatira malamulo, ndi njira zochiritsira zofananira.