‌N-Acetylcysteine

Lambar CAS: 616-91-1

Tsarin kwayoyin halitta: C₅H₉NO₃S

Nauyin Kwayoyin Halitta: 163.20

EINECS NO.: 211-806-2

Acetylcysteine ​​​​(NAC) a cikin Magungunan Dabbobi: Babban Ayyuka, Aikace-aikace, da Sharuɗɗa

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"I. Core Mechanisms and Therapeutic Effects"

"1. Detoxification da Hepatoprotection"

"Acetaminophen (Paracetamol) Guba"

• "Makanikai‌: Yana sake cika glutathione (GSH) don kawar da metabolites masu guba na NAPQI, yana hana necrosis na hanta.
• "Application‌: Maganin gaggawa ga karnuka/masu shan magungunan da ke ɗauke da acetaminophen (misali, maganin sanyi).

"Sashi70-140 mg / kg IV ko baki, maimaita kowane 4-6 hours.

• "inganci‌:> 60% haɓaka ƙimar rayuwa idan an gudanar da shi a cikin sa'o'i 8 bayan guba.

"Ƙarfe mai nauyi da Tsare-tsare"

• "Chelation‌: Yana ɗaure gubar/mercury ta ƙungiyoyin sulfhydryl (-SH) (sau da yawa haɗe da EDTA).
• "Mycotoxin Detox‌: Yana rage lalacewar hanta aflatoxin B1 a cikin kaji (200 mg/kg NAC yana rage ALT da 50%).

"2. Kula da Cututtuka na Numfashi"

"Mucolytic da Expectorant Effects"

• "Aiki‌: Yana karya ginshiƙan disulfide a cikin gamsai, yana rage danko da haɓaka iska.
• "Alamu:
  • "Dabbobi: Bronchitis, ciwon huhu (tari / dyspnea).
  • "Dabbobi‌: Cututtukan ƙwayoyin cuta/virus na numfashi (misali, ciwon huhu na huhu).
• "Gudanarwa:
  • Nebulization (3-5% bayani) ko na baka (10-20 mg / kg BID).

"Anti-mai kumburi da Immunomodulatory Effects"

• "Makanikai‌: Yana hana IL-6, TNF-a, kuma yana rage kumburi na yau da kullun (misali, toshewar hanyar iska mai maimaita equine).

"3. Antioxidant da Anti-stress Properties"

"Kariyar Danniya mai Oxidative"

• "Makanikai‌: Yana haɓaka GSH intracellular, yana lalata radicals kyauta, kuma yana kare mutuncin salon salula.
• "Aikace-aikace:
  • "Kaji‌: Rage damuwa mai zafi (100 mg/kg NAC a cikin abinci yana inganta samar da kwai da 5-8%).
  • "Kiwo‌: Yana rage lalacewar oxidative a lokacin sufuri/yawan noma.

"Haɓaka rigakafi"

• Yana ƙarfafa yaduwar lymphocyte kuma yana haɓaka ingancin rigakafin (misali, rigakafin zazzabin alade).

"III. Kariyar Amfani"

"Sarrafa sashi:

• Yawan wuce gona da iri na iya haifar da amai/zawo (musamman a cikin monogastrics); jinkirin jiko na IV don guje wa hypotension.
• Shirya mafita na NAC sabo don kiwon kaji (mai saurin iskar oxygen a cikin ruwa).

"Mu'amalar Magunguna:

Guji amfani tare da oxidizers (misali, potassium permanganate) ko maganin rigakafi (misali, penicillin); gudanar 2 hours baya.

"Yarda da Ka'ida:

• "EU‌: An amince da takamaiman alamomi (misali, detox) tare da iyakoki na saura a cikin dabbobin abinci.
• "China: bi Dokokin Gudanar da Magungunan Dabbobida lokutan janyewa.

"IV. Ci gaban Bincike da Yiwuwar Amfani"

• "Antiviral Adjunct‌: Yana hana kwafin PRRSV a cikin vitro (50 μM ingantaccen taro).
• "Lafiyar Haihuwa‌: Yana inganta ingancin maniyyi a cikin bijimai (kamar 15% na motsin maniyyi).

"V. Takaitawa"

Acetylcysteine ​​​​yana aiki azaman ginshiƙi a cikin magungunan dabbobi don ‌detoxification, goyon bayan antioxidant, da kuma kula da numfashi, magance matsalolin gaggawa na guba, cututtuka na yau da kullum, da matsalolin muhalli. Amintaccen aiki mai inganci yana buƙatar takamaiman nau'in nau'in allurai, bin ƙa'idodi, da ingantattun dabarun warkewa.