‌N-Acetylcysteine

Nọmba CAS: 616-91-1

Usoro ihe omimi: C₅H₉NO₃S

Arọ Molecular: 163.20

EINECS NO.: 211-806-2

Acetylcysteine ​​​​(NAC) na ọgwụgwọ ọrịa anụmanụ: Ọrụ bụ isi, ngwa, na ntuziaka

;

;I. Usoro isi na mmetụta ọgwụgwọ;

;1. Detoxification na Hepatoprotection;

;Acetaminophen (Paracetamol) na-egbu egbu;

• ;Mechanism‌: Na-ejuputa glutathione (GSH) iji kpochapụ metabolites NAPQI na-egbu egbu, na-egbochi necrosis imeju.
• ;Application‌: Ọgwụgwọ mberede maka nkịta/nwamba na-eri ọgwụ nwere acetaminophen (dịka ọmụmaatụ, ọgwụgwọ oyi).

;Usoro onunu ogwu70-140 mg / kg IV ma ọ bụ ọnụ, ugboro ugboro ọ bụla 4-6 awa.

• ;Ịrụ ọrụ‌:> 60% nwelite ọnụego nlanarị ma ọ bụrụ na etinyere ya n'ime awa 8 mgbe nsị gasịrị.

;Mkpochapụ ọla dị arọ na nsị;

• ;Chelation‌: Na-ejikọta ndu/mercury site na otu sulfhydryl (-SH) (na-ejikọta ya na EDTA).
• ;Mycotoxin Detox‌: Na-ebelata mmebi imeju nke aflatoxin B1 na anụ ọkụkọ (200 mg/kg NAC na-ebelata ALT site na 50%).

;2. Nlekọta Ọrịa iku ume;

;Mmetụta Mucolytic na Expectorant;

• ;Omume: Na-agbaji njikọ disulfide na imi, na-ebelata viscosity na imeziwanye ikuku.
• ;Ngosipụta:
  • ;Anụ ụlọ: Bronchitis, oyi baa (ụkwara / dyspnea).
  • ;Anụ anụỌrịa nje na-efe efe na-efe efe na-efe efe (dịka ọmụmaatụ, pneumonia enzootic ezì).
• ;nchịkwa:
  • Nebulization (3-5% ngwọta) ma ọ bụ ọnụ (10-20 mg / kg BID).

;Mmetụta mgbochi mkpali na immunomodulatory;

• ;Mechanism‌: Na-egbochi IL-6, TNF-a, ma na-ebelata mbufụt na-adịghị ala ala (dịka ọmụmaatụ, equine na-emegharị ikuku ikuku).

;3. Antioxidant na Anti-stress Properties;

;Nchekwa nrụgide Oxidative;

• ;Mechanism‌: Na-akwalite GSH intracellular, na-ekpochapụ radicals efu, ma na-echekwa iguzosi ike n'ezi ihe nke ekwentị.
• ;Ngwa:
  • ;Anụ ọkụkọ‌: Mbelata nrụgide okpomọkụ (100 mg/kg NAC na nri na-eme ka mmepụta akwa dị mma site na 5-8%).
  • ;Aquaculture‌: Na-ebelata mmebi oxidative n'oge njem / njupụta dị elu.

;Ịkwalite ọrịa mgbochi;

• Na-akpali mgbasa nke lymphocyte ma na-akwalite nrụpụta ọgwụ mgbochi (dịka ọmụmaatụ, ịgba ọgwụ mgbochi ezì).

;III. Akpachara anya ojiji;

;Njikwa onunu ogwu:

• Ịṅụbiga mmanya ókè nwere ike ịkpata vomiting/afọ ọsịsa (karịsịa na monogastrics); ngwa ngwa IV infusion iji zere hypotension.
• Kwadebe NAC ngwọta ọhụrụ maka anụ ọkụkọ (ngwa ngwa oxidation na mmiri).

;Mmekọrịta ọgwụ:

Zere iji oxidizers (dịka ọmụmaatụ, potassium permanganate) ma ọ bụ ọgwụ nje (dịka ọmụmaatụ, penicillin); inye 2 awa iche.

;Nrube isi n'usoro:

• ;EU‌: Ekwenyere maka ihe ngosi akọwapụtara (dịka ọmụmaatụ, detox) nwere oke fọdụrụ na anụmanụ nri.
• ;China: Soro Iwu maka nchịkwa ọgwụ anụmanụna oge nkwụsị.

;IV. Ọganihu nyocha na ojiji enwere ike;

• ;Ihe mgbochi mgbochi‌: Na-egbochi mmegharị PRRSV na vitro (50 μM ntinye dị irè).
• ;Ahụike ọmụmụ‌: Na-eme ka mma mkpụrụ ndụ dị na oke ehi (15% na-abawanye na motility sperm).

;V. Nchịkọta;

Acetylcysteine ​​​​na-eje ozi dị ka isi nkuku na ọgwụgwọ ọrịa anụmanụ maka ‌detoxification, nkwado antioxidant, na nlekọta iku ume‌, na-egbo mkpa mberede nsi, ọrịa na-adịghị ala ala, na nrụgide gburugburu ebe obibi. Ngwa dị mma ma dị irè chọrọ usoro ọgwụgwọ ụdị-kpọmkwem, nrube isi n'ụkpụrụ, yana usoro ọgwụgwọ ahaziri.