N-Acetylcysteine

CAS No.: 616-91-1

Qaacidada Molecular:C₅H₉NO₃S

Miisaanka Molecular:163.20

EINECS NO.: 211-806-2

Acetylcysteine ​​(NAC) ee Daawada Xoolaha: Hawlaha Muhiimka ah, Codsiyada, iyo Tilmaamaha

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?I. Farsamooyinka Muhiimka ah iyo Saamaynta Daweynta?

?1. Sun-saarid iyo difaacid cagaarshow?

?Acetaminophen (Paracetamol) suntan?

• ?Farsamaynta‌: Waxay buuxisaa glutathione (GSH) si ay u baabi'iso dheef-shiid kiimikaadka sunta ah ee NAPQI, ka hortagga necrosis cagaarshow.
• ?Codsiga‌: Daawaynta degdega ah ee eeyaha/bisadaha raaca daawooyinka ay ku jirto acetaminophen (tusaale, dawooyinka qabowga).

?Qiyaasta70-140 mg/kg IV ama afka, soo noqnoqda 4-6 saacadood kasta.

• ?Waxtarka‌:> 60% hagaajinta heerka badbaadada haddii lagu maamulo 8 saacadood gudahooda sunta kadib.

?Nadiifinta Birta Culus iyo Sunta?

• ?Chelation‌: Waxay ku xidhaa macdanta "lead/mercury" iyada oo loo sii marayo kooxaha sulfhydryl (-SH) (badanaa lagu daro EDTA).
• ?Mycotoxin Detox‌: Waxay yaraynaysaa dhaawaca beerka ee aflatoxin B1 ee digaaga (200 mg/kg NAC waxay hoos u dhigtaa ALT 50%).

?2. Maareynta Cudurrada Neefsashada?

?Saamaynta Mucolytic iyo Rajada?

• ?Ficil: Wuxuu jebiyaa xab-xabxab-xabeedka-disulfide-ka, hoos u dhigidda viscosity-ga iyo hagaajinta socodka hawada.
• ?Tilmaamaha:
  • ?Xayawaanka: boronkiitada, oof wareenka (qufac/ dyspnea).
  • ?Xoolaha‌: Caabuqyada neef-mareenka ee bakteeriyada/ fayraska (tusaale, sambabada enzootic doofaarka).
• ?Maamulka:
  • Nebulization (3-5% xal) ama afka (10-20 mg/kg BID).

?Ka-hortagga-bararka iyo Saamaynta Immunomodulatory?

• ?Farsamaynta‌: Waxay xakamaysaa IL-6, TNF-a, waxayna yaraynaysaa bararka dabadheeraad ah (tusaale, xannibaado soo noqnoqda oo siman).

?3. Antioxidant and Anti-stress Properties?

?Ilaalinta Cadaadiska Oxidative?

• ?Farsamaynta‌: Waxay kordhisaa GSH-ga unugyada, waxay baabi'isaa xag-jirrada xorta ah, waxayna ilaalisaa daacadnimada gacanta.
• ?Codsiyada:
  • ?Digaagga‌: Yaraynta cadaadiska kulaylka (100 mg/kg NAC ee quudinta waxay hagaajisaa wax soo saarka ukunta 5-8%).
  • ?Aquaculture: Waxay yaraynaysaa waxyeelada oksaydhka inta lagu jiro gaadiidka/beerashada cufnaanta sare leh.

?Kobcinta difaaca jirka?

• Waxay kicisaa fidinta lymphocyte waxayna xoojisaa waxtarka tallaalka (tusaale, tallaalka xumadda doofaarka).

?III. Kahortagga Isticmaalka?

?Xakamaynta qiyaasta:

• Qaadashada xad dhaafka ah waxay keeni kartaa matag/shuban (gaar ahaan kuwa monogastrics ah); faleebo IV tartiib ah si looga fogaado hypotension.
• U diyaari xalalka NAC ee cusub ee digaaga (oxidation degdeg ah ee biyaha).

?Isdhexgalka daroogada:

Iska ilaali isticmaalka isku mar ah oksidizers (tusaale, potassium permanganate) ama antibiyootiga (tusaale, penicillin); maamul 2 saacadood u dhexeeya.

?U Hogaansanaanta Nidaaminta:

• ?EU‌: Loo oggolaaday tilmaamo gaar ah (tusaale, sun-saar) oo leh xaddidaad haraaga xoolaha cuntada ah.
• ?Shiinaha: Raac Xeerarka Maamulka Dawooyinka Xoolahaiyo xilliyada ka bixida.

?IV. Horumarka Cilmi-baarista iyo Isticmaalka Suurtogalka ah?

• ?Adjunct Antiviral‌: Waxay joojisaa ku-noqoshada PRRSV gudaha vitro (50 μM xooga saarista waxtarka leh).
• ?Caafimaadka Taranka‌: Waxay wanaajisaa tayada shahwada ee dibida (15% waxay kordhisaa dhaqdhaqaaqa shahwada).

?V. Kooban?

Acetylcysteine ​​waxay u adeegtaa sidii dhagaxa rukun ee daawaynta xoolaha ee ‌sun-saarid, taageerada antioxidant, iyo daryeelka neefsashadaWax ka qabashada xaaladaha degdegga ah ee sumowga ah, cudurrada daba-dheeraada, iyo walbahaarka deegaanka. Codsiga badbaadada iyo waxtarka leh wuxuu u baahan yahay qiyaas nooc-gaar ah, u hoggaansanaanta qawaaniinta, iyo xeelado daweyn oo habaysan.