N-Acetylcysteine

CAS No.: 616-91-1

Fọọmu Molecular:C₅H₉NO₃S

Òṣuwọn Molecular:163.20

EINECS ỌRỌ: ‌211-806-2

Acetylcysteine ​​​​(NAC) ni Oogun ti ogbo: Awọn iṣẹ pataki, Awọn ohun elo, ati Awọn Itọsọna

o

oI. Awọn ọna ẹrọ Core ati Awọn ipa Itọju ailerao

o1. Detoxification ati Hepatoprotectiono

oAcetaminophen (Paracetamol) Majeleo

• oIlana‌: Replenishes glutathione (GSH) lati yomi majele ti NAPQI metabolites, idilọwọ negirosisi ẹdọ.
• oOhun elo‌: Itọju pajawiri fun awọn aja/ologbo ti n gba awọn oogun ti o ni acetaminophen ninu (fun apẹẹrẹ, awọn atunṣe tutu).

oIwọn lilo70-140 mg / kg IV tabi ẹnu, tun ṣe ni gbogbo wakati 4-6.

• oAgbara‌:> 60% ilọsiwaju oṣuwọn iwalaaye ti o ba jẹ abojuto laarin awọn wakati 8 lẹhin majele.

oEru Irin ati Majele Kiliaransio

• oChelation‌: Din asiwaju/mercury nipasẹ awọn ẹgbẹ sulfhydryl (-SH) (nigbagbogbo ni idapo pẹlu EDTA).
• oMycotoxin Detox‌: Din aflatoxin B1-induced ẹdọ bibajẹ ninu adie (200 mg/kg NAC lowers ALT nipa 50%).

o2. Iṣakoso Arun Aruno

oMucolytic ati Expectorant Ipao

• oIṣe‌: Fọ awọn ifunmọ disulfide ni mucus, idinku iki ati imudarasi ṣiṣan afẹfẹ.
• oAwọn itọkasi:
  • oOhun ọsin: Bronchitis, pneumonia (ikọaláìdúró/ dyspnea).
  • oẸran-ọsin‌: Kokoro/arun atẹgun ti o gbogun ti (fun apẹẹrẹ, pneumonia enzootic ẹlẹdẹ).
• oIsakoso:
  • Nebulization (3-5% ojutu) tabi ẹnu (10-20 mg / kg BID).

oAnti-iredodo ati Awọn ipa Immunomodulatoryo

• oIlana‌: Dinku IL-6, TNF-a, ati pe o dinku iredodo onibaje (fun apẹẹrẹ, idinamọ ọna atẹgun loorekoore equine).

o3. Antioxidant ati Anti-wahala Propertieso

oOxidative Wahala Idaaboboo

• oIlana‌: Ṣe igbelaruge GSH intracellular, ṣe apanirun awọn ipilẹṣẹ ọfẹ, ati aabo fun iduroṣinṣin cellular.
• oAwọn ohun elo:
  • oAdie‌: Imukuro aapọn ooru (100 mg/kg NAC ni kikọ sii ṣe ilọsiwaju iṣelọpọ ẹyin nipasẹ 5–8%).
  • oAquaculture‌: Din bibajẹ oxidative lakoko gbigbe / ogbin iwuwo giga.

oImudara Ajẹsarao

• Ti nmu ilọsiwaju lymphocyte soke ati imudara ipa ajesara (fun apẹẹrẹ, ajesara iba ẹlẹdẹ).

oIII. Awọn iṣọra Liloo

oIṣakoso doseji:

• Aṣeju iwọn lilo le fa eebi/gbuuru (paapaa ni monogastrics); Idapo IV lọra lati yago fun hypotension.
• Mura awọn ojutu NAC tuntun fun adie (ifoyina iyara ninu omi).

oOògùn Awọn ibaraẹnisọrọ:

Yago fun lilo nigbakanna pẹlu oxidizers (fun apẹẹrẹ, potasiomu permanganate) tabi awọn egboogi (fun apẹẹrẹ, penicillin); ṣakoso awọn wakati 2 lọtọ.

oIbamu Ilana:

• oEU‌: Ti fọwọsi fun awọn itọkasi kan pato (fun apẹẹrẹ, detox) pẹlu awọn opin aloku ninu awọn ẹranko ounjẹ.
• oChina: Tẹle Awọn ilana lori Isakoso ti Awọn oogun ti ogboati yiyọ akoko.

oIV. Awọn ilọsiwaju Iwadi ati Awọn Lilo O pọjuo

• oAntiviral Adjunct‌: Idilọwọ awọn atunṣe PRRSV in vitro (50 μM ifọkansi ti o munadoko).
• oIlera ibisi‌: Ṣe ilọsiwaju didara àtọ ni awọn akọmalu (15% ilosoke ninu motility sperm).

oV. Akopọo

Acetylcysteine ​​​​ṣiṣẹ bi okuta igun ile ni oogun ti ogbo fun ‌detoxification, atilẹyin antioxidant, ati itọju atẹgun‌, koju awọn pajawiri oloro, awọn arun onibaje, ati awọn aapọn ayika. Ohun elo to ni aabo ati imunadoko nilo iwọn lilo-ẹya kan pato, ifaramọ awọn ilana, ati awọn ilana itọju ailera ti a ṣe deede.