‌N-Acetylcysteine

CAS No.: 616-91-1

Inzira ya molekulari: C₅H₉NO₃S

Uburemere bwa molekuline: 163.20

EINECS OYA: ‌211-806-2

Acetylcysteine ​​(NAC) mubuvuzi bwamatungo: Imikorere yibanze, ikoreshwa, nubuyobozi

‌

‌I. Uburyo bukuru ningaruka zo kuvura‌

‌1. Kwangiza no Hepatoprotection‌

‌Uburozi bwa Acetaminofeni (Paracetamol)‌

• ‌Urwego‌: Yuzuza glutathione (GSH) kugirango yanduze metabolite yubumara ya NAPQI, ikingira indwara ya hepatike.
• ‌Gusaba‌: Kuvura byihutirwa imbwa / injangwe zifata imiti irimo acetaminofeni (urugero, imiti ikonje).

‌Umubare‌: 70-140 mg / kg IV cyangwa mu kanwa, bigasubirwamo buri masaha 4-6.

• ‌Ingaruka:> 60% kurokoka igipimo cyo kubaho iyo bitangwa mugihe cyamasaha 8 nyuma yuburozi.

‌Ibyuma biremereye hamwe nuburozi‌

• ‌Chelation‌: Guhuza kuyobora / mercure ukoresheje sulfhydryl (-SH) (akenshi bihujwe na EDTA).
• ‌Mycotoxin‌: Kugabanya aflatoxine B1 iterwa numwijima winkoko (200 mg / kg NAC igabanya ALT 50%).

‌2. Gucunga indwara zubuhumekero‌

‌Ingaruka za Mucolytic na Expectorant‌

• ‌Igikorwa‌: Kumena imiyoboro ya disulfide mumitsi, kugabanya ubukonje no kunoza umwuka.
• ‌Ibyerekana‌:
  • ‌Ibikoko bitungwa‌: Bronchitis, umusonga (inkorora / dyspnea).
  • ‌Amatungo‌: Indwara z'ubuhumekero za bagiteri / virusi (urugero, umusonga w'ingurube enzootic pneumonia).
• ‌Ubuyobozi‌:
  • Nebulisation (3-5% igisubizo) cyangwa umunwa (10-20 mg / kg BID).

‌Kurwanya-inflammatory na Immunomodulatory Ingaruka‌

• ‌Urwego‌: Irwanya IL-6, TNF-α, kandi igabanya ubukana bwa karande (urugero, guhagarika inzira yo guhumeka inshuro nyinshi).

‌3. Antioxydants na Anti-stress Ibintu byiza‌

‌Kurinda Oxidative Stress‌

• ‌Urwego‌: Itezimbere GSH idasanzwe, ikuraho radicals yubuntu, kandi ikarinda ubusugire bwimikorere.
• ‌Porogaramu‌:
  • ‌Inkoko‌: Kugabanya ubushyuhe (100 mg / kg NAC mu biryo byongera umusaruro w'amagi 5-8%).
  • ‌Ubworozi bw'amafi‌: Kugabanya kwangirika kwa okiside mugihe cyo gutwara / guhinga cyane.

‌Kongera Immune‌

• Itera ikwirakwizwa rya lymphocyte kandi ikongerera imbaraga urukingo (urugero, urukingo rw’ingurube).

‌III. Imikoreshereze‌

‌Kugenzura Imikoreshereze‌:

• Kurenza urugero birashobora gutera kuruka / impiswi (cyane cyane muri monogastrics); gahoro gahoro IV kugirango wirinde hypotension.
• Tegura ibisubizo bya NAC bishya kubiguruka (okiside yihuse mumazi).

‌Imikoreshereze yibiyobyabwenge‌:

Irinde gukoresha icyarimwe hamwe na okiside (urugero, potasiyumu permanganate) cyangwa antibiotike (urugero, penisiline); kuyobora amasaha 2 atandukanye.

‌Kubahiriza amabwiriza‌:

• ‌EU‌: Yemejwe kubimenyetso byihariye (urugero, disox) hamwe nimbibi zisigaye mubikoko byibiribwa.
• ‌Ubushinwa‌: Kurikira Amabwiriza ku micungire y’ibiyobyabwenge byamatungon'ibihe byo kubikuramo.

‌IV. Iterambere ryubushakashatsi nibishobora gukoreshwa‌

• ‌Kurwanya virusi‌: Irabuza kwigana PRRSV muri vitro (50 μM yibanda cyane).
• ‌Ubuzima bw'imyororokere.

‌V. Incamake‌

Acetylcysteine ​​ikora nk'ifatizo mu buvuzi bw'amatungo ya ‌kwangiza, inkunga ya antioxydeant, no kwita kubuhumekero‌, gukemura ibibazo byihutirwa byuburozi, indwara zidakira, hamwe n’ibidukikije. Gukoresha neza kandi neza bisaba amoko yihariye, kubahiriza amabwiriza, hamwe nuburyo bwo kuvura.