‌N-Acetylcysteine

Ka helu CAS: 616-91-1

Huina Molekala:C₅H₉NO₃S

Kaumaha Molekala:163.20

NĀ EINECS: 211-806-2

ʻO Acetylcysteine ​​​​(NAC) i ka lāʻau lapaʻau holoholona: nā hana kumu, nā noi, a me nā alakaʻi.

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?I. Mechanisms Core and Therapeutic Effects?

?1. Detoxification a me Hepatoprotection?

?Acetaminophen (Paracetamol) Poisoning?

• ?Mechanism‌ : Hoʻopiha hou i ka glutathione (GSH) e hoʻopau i nā metabolites NAPQI ʻona, e pale ana i ka necrosis hepatic.
• ?Application‌ : Ka lāʻau ulia pōpilikia no nā ʻīlio/pīkī e ʻai ana i nā lāʻau lapaʻau i loaʻa i ka acetaminophen (e laʻa, nā lāʻau lapaʻau anu).

?ʻAiʻai‌: 70–140 mg/kg IV a i ʻole ma ka waha, hana hou ʻia i kēlā me kēia 4-6 hola.

• ?Ka pono‌: >60% ka hoʻomaikaʻi ʻana i ka helu ola inā lawelawe ʻia i loko o 8 mau hola ma hope o ka make ʻana.

?Hoʻomaʻemaʻe metala kaumaha a me ka ʻawaʻawa?

• ?ʻO Chelation‌ : Hoʻopaʻa i ke alakaʻi/mercury ma o nā pūʻulu sulfhydryl (-SH) (hui pinepine me EDTA).
• ?Mycotoxin Detox‌ : Hoemi i ka poino o ke akepaʻa i hoʻokomo ʻia aflatoxin B1 i ka moa (200 mg/kg NAC e hoʻemi i ka ALT ma 50%).

?2. Hooponopono ma'i hanu?

?Nā hopena Mucolytic a me Expectorant?

• ?Hana‌ : Wehe i nā mea paʻa disulfide i loko o ka mucus, e hōʻemi ana i ka viscosity a me ka hoʻomaikaʻi ʻana i ka ea.
• ?Nā hōʻailona:
  • ?Pets‌ : ʻO ka maʻi maʻi maʻi, ka maʻi maʻi maʻi (ka maʻi / dyspnea).
  • ?holoholona‌ : Nā maʻi hanu bacteria/viral (e laʻa, puaʻa enzootic pneumonia).
• ?Hooponopono:
  • Nebulization (3–5% solution) a i ʻole waha (10-20 mg/kg BID).

?Nā hopena anti-inflammatory a me Immunomodulatory?

• ?Mechanism‌ : Kāohi i ka IL-6, TNF-α, a hoʻēmi i ka ʻaʻa mau ʻana (e laʻa, keakea ʻana o ke ea equine).

?3. Mea Antioxidant a me Anti-stress Properties?

?ʻO ka pale ʻana i ke koʻikoʻi?

• ?Mechanism‌ : Hoʻonui i ka GSH intracellular, hoʻopaʻa i nā radical manuahi, a pale i ka pono o nā kelepona.
• ?Nā noi:
  • ?Ka moa‌ : ʻO ka hoʻohaʻahaʻa ʻana i ka wela (100 mg/kg NAC i ka hānai e hoʻomaikaʻi i ka hana hua manu e 5-8%).
  • ?ʻAiʻa‌ : Hoʻemi i ka pōʻino oxidative i ka wā o ka lawe ʻana / mahiʻai kiʻekiʻe.

?Hoʻoikaika kino?

• Hoʻoulu i ka hoʻonui ʻana o nā lymphocyte a hoʻonui i ka pono o ka lāʻau lapaʻau (e laʻa, ka lāʻau lapaʻau puaʻa).

?III. Hoʻohana ʻia?

?Hoʻoponopono i ka Dosage:

• Hiki i ka overdose ke hoʻoulu i ka luaʻi/ka maʻi paʻi (ʻoi loa i ka monogastrics); lohi IV infusion e pale aku i ka hypotension.
• E hoʻomākaukau i nā hoʻonā NAC hou no ka moa (wikiwiki oxidation i ka wai).

?Pilikia laau:

Hōʻalo i ka hoʻohana like ʻana me nā oxidizers (e laʻa, potassium permanganate) a i ʻole nā ​​​​antibiotic (e laʻa, penicillin); lawelawe 2 hola kaawale.

?Hoʻokō hoʻoponopono:

• ?EU‌ : ʻApono ʻia no nā hōʻailona kikoʻī (e laʻa, detox) me nā palena koena i nā holoholona meaʻai.
• ?Kina: Hahai Nā hooponopono no ka hooponopono ana i na laau lapaau holoholonaa me nā wā huki.

?IV. Noiʻi mua a me ka hiki ke hoʻohana?

• ?Pākuʻi Antiviral‌ : Kāohi i ka hana hou ʻana o PRRSV in vitro (50 μM ka manaʻo kūpono).
• ?Ola Hanau‌ : Hoʻomaikaʻi i ka maikaʻi o ka semen i nā bipi (15% ka piʻi ʻana o ka motility sperm).

?V. Hōʻuluʻulu manaʻo?

Hana ʻo Acetylcysteine ​​​​ma ke ʻano he pōhaku kihi i ka lāʻau lapaʻau holoholona no ‌detoxification, kākoʻo antioxidant, a me ka mālama hanu‌, ka hoʻoponopono ʻana i nā pilikia ʻawaʻawa, nā maʻi maʻi mau, a me nā pilikia kūlohelohe. Pono ka hoʻohana palekana a me ka maikaʻi i ka hoʻopaʻa ʻana i nā ʻano ʻano, ka mālama ʻana i nā lula, a me nā hoʻolālā lapaʻau kūpono.