N-Acetylcysteine

Nhamba yeCAS: 616-91-1

Molecular Formula:C₅H₉NO₃S

Masikuru Kurema: 163.20

EINECS NHORA: 211-806-2

Acetylcysteine ​​(NAC) muVeterinary Medicine: Core Functions, Applications, uye Guidelines.

,

,I. Core Mechanisms uye Therapeutic Effects,

,1. Detoxification uye Hepatoprotection,

,Acetaminophen (Paracetamol) Chepfu,

• ,Mechanism: Inozadza glutathione (GSH) kuderedza chepfu NAPQI metabolites, kudzivirira hepatic necrosis.
• ,Application: Kurapwa kwechimbichimbi kwembwa/katsi dzinonwa mishonga ine acetaminophen (semuenzaniso, mishonga inotonhora).

,Dosage: 70–140 mg/kg IV kana nemuromo, inodzokororwa maawa 4–6 oga oga.

• ,Efficacy: > 60% yekuvandudza mwero wekupona kana ikashandiswa mukati memaawa masere mushure mekuita chepfu.

,Heavy Metal uye Toxin Clearance,

• ,Chelation: Inosunga lead/mercury kuburikidza ne sulfhydryl (-SH) mapoka (kazhinji akasanganiswa neEDTA).
• ,Mycotoxin Detox: Inoderedza aflatoxin B1-inokonzerwa nekukuvara kwechiropa muhuku (200 mg/kg NAC inodzikisa ALT ne50%).

,2. Respiratory Disease Management,

,Mucolytic uye Expectorant Migumisiro,

• ,Chiito: Inotyora zvisungo zve disulfide mucus, kuderedza viscosity uye kunatsiridza kuyerera kwemhepo.
• ,Zviratidzo:
  • ,Zvipfuyo: Bronchitis, mabayo (chikosoro/dyspnea).
  • ,Zvipfuyo: Utachiona hwebhakitiriya/hutachiona hwekufema (semuenzaniso, pneumonia enzootic yenguruve).
• ,Administration:
  • Nebulization (3-5% mhinduro) kana nemuromo (10-20 mg/kg BID).

,Anti-inflammatory uye Immunomodulatory Effects,

• ,Mechanism: Inodzvanya IL-6, TNF-α, uye inoderedza kuzvimba kusingaperi (semuenzaniso, kudzokororwa kwemhepo kuvharika).

,3. Antioxidant uye Anti-stress Properties,

,Oxidative Stress Dziviriro,

• ,Mechanism: Inosimudzira intracellular GSH, inoparadza mahara radicals, uye inodzivirira kuvimbika kweserura.
• ,Applications:
  • ,Huku: Kuderedza kushushikana kwekupisa (100 mg/kg NAC muchikafu inovandudza kugadzirwa kwezai ne5–8%).
  • ,Aquaculture: Inoderedza kukuvadzwa kweoxidative panguva yekufambisa / yakakwirira-density kurima.

,Kuwedzera Kudzivirira Kwemuviri,

• Inokurudzira kuwedzera kwe lymphocyte uye inowedzera kushanda kwejekiseni (semuenzaniso, kubaya kwenguruve fever).

,III. Usage Precautions,

,Dosage Control:

• Overdose inogona kukonzera kurutsa / manyoka (kunyanya mune monogastrics); inononoka IV infusion kudzivirira hypotension.
• Gadzirira mhinduro dzeNAC nyowani dzehuku (kukurumidza oxidation mumvura).

,Kudyidzana Kwezvinodhaka:

Dzivisa kushandiswa panguva imwe chete neoxidizers (semuenzaniso, potassium permanganate) kana mishonga inorwisa mabhakitiriya (semuenzaniso, penicillin); shandisa maawa maviri akasiyana.

,Regulatory Compliance:

• ,EU: Yakatenderwa kune chaiwo zviratidzo (semuenzaniso, detox) ine zvisaririra mumhuka dzekudya.
• ,China: Teverai Mitemo pamusoro peKutungamirirwa kweVeterinary Drugsuye nguva dzekubvisa.

,IV. Tsvagiridzo Yemberi uye Inogona Kushandiswa,

• ,Antiviral Adjunct: Inodzivisa kudzokorora kwePRRSV mu vitro (50 μM inobudirira yekufungisisa).
• ,Utano Hwokubereka: Inovandudza kunaka kwembeu mumabhuru (15% kuwedzera kwembeu motility).

,V. Pfupiso,

Acetylcysteine ​​​​inoshanda sedombo repakona mumushonga wezvipfuyo wedetoxification, antioxidant tsigiro, uye kuchengetedza kufema, kugadzirisa chepfu yekukurumidzira, zvirwere zvisingaperi, uye zvinonetsa kwezvakatipoteredza. Kushandisa kwakachengeteka uye kunoshanda kunoda mhando-chaiyo dosing, kutevedzera mirau, uye akagadzirirwa nzira dzekurapa.